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KMID : 0894319970060010151
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Dongguk Journal of the Institute of Oriental Medicine
1997 Volume.6 No. 1 p.151 ~ p.161
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Effect of Eriobotryae folium extract on glucokinase and hexokinase activities of alloxan-induced diabetes mellitus mice
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鄭昌煥/Jeong, Chang-Hwan
尹哲浩/鄭智天/金鐵虎/Yoon, Cheol-Ho/Jeong, Ji-Cheon/Kim, Cheorl-Ho
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Abstract
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We have investigated the in vivo. effect of an aqeuous extract from Eriobotryae folium on glucokinase and hexokinase activities of diabetes mellitus induced by alloxan. After 1 week of alloxan injection, the levels of serum glucose and insulin secretion were dramatically increased, however, the insulin secretion was decreased with administration of Eriobotryae folium. Alloxan injection allowed the serum glucose level increased and the level was decreased by Eriobotryae folium administration. Furthermore, it was observed that Eriobotryae folium was effective in recovering the levels of insulin secretion. Enzyme activities of the glucokinase and hexokinase were decreased by alloxan treatment. In contrast, Eriobotryae folium administration to the mice allowed proportional increasing. These results suggested that Eriobotryae folium is highly effective in treatment of diabetes mellitus induced by alloxan.
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